Which of the following is considered a sign of major mental deterioration?

Confusion due to drugs and chemicals is recognized as a sign of major mental deterioration because it indicates a significant impact on cognitive function. This confusion can stem from the effects of various substances, whether they are prescribed medications, illegal drugs, or toxic chemicals that impair a person’s ability to think clearly, make decisions, and process information effectively. Deterioration in mental capabilities suggests that the individual's mental health is compromised, which is a core concern in the field of medication assistance and care.

In contrast, increased appetite might suggest varied psychological or physical conditions but does not necessarily indicate mental deterioration. Improved memory recall and enhanced physical coordination suggest a positive trend in cognitive and physical functioning, which would be the opposite of mental deterioration.