Which term describes the gradual loss of effectiveness of a medication over time?

Tolerance describes the gradual loss of effectiveness of a medication over time. This phenomenon occurs when a person regularly uses a medication, and over time, their body becomes accustomed to its effects. As a result, individuals may require higher doses to achieve the same therapeutic effect that was initially experienced with a lower dose. This is a common occurrence with many medications, including pain relievers and some psychological medications.

In contrast, the other terms have distinct meanings. Synergism refers to the interaction between two or more substances where their combined effects are greater than the sum of their individual effects. Withdrawal describes symptoms that occur when a person stops taking a medication after prolonged use which their body has adjusted to. Saturation is a term often used to describe the point at which a medication reaches its maximum effect and no further increases in response can be achieved, but it does not imply a decrease in effectiveness over time. Understanding these distinctions is crucial for effectively recognizing how medications work and ensuring proper usage and management in patient care.